Statins: Uses & Side Effects

It seems like every large pharmaceutical company offers up their very own take on statins. And it’s easy to see why. Statin use has increased substantially over the last decade, and the numbers show no sign of slowing down.

But what are statins, what are they used for, and what are the most prominent side effects? Today, we’re going to take a deep dive on all things statin, so that you can make a more informed decision if or when that day comes. Let’s go!

What Are Statins?

Over 50-percent of the adult population in high-income countries is affected by high cholesterol. In fact, roughly 28.5 million Americans suffer from high cholesterol. Even if only half of those people seek pharmaceutical aid, that’s still a lot of people.

Pharmaceutical aid is available, and it usually comes in the form of statins. Statins are a class of drugs designed to help lower the blood’s cholesterol levels as a means to prevent heart attacks and strokes. And statins do accomplish this goal in a lot of people. The statistics show statins are responsible for reducing the risk of heart attack, stroke, and heart disease-related fatalities by 25-percent to 35-percent.

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Types of Statins

There are numerous variations on the statin class of drug, all of which offer similar benefits and side effects, with slight variations of course.

Lipitor, Lescol, Mevacor, Altoprev, Pravachol, Crestor, and Zocor are the main statins available. Although if you need to make a choice on which statin is best for you, we strongly advise relying on your doctor’s recommendation.

Who Should Use Statins?

Remember those 28.5-million Americans with high cholesterol? It’s important to note that not all of them use statins to protect themselves from heart disease. In fact, it’s estimated that another 15 to 20-million people should be.

Though it is relatively common, high levels of LDL cholesterol in your blood is indeed a bad thing, as it can dramatically increase your risk of developing heart disease. Not all cholesterol is bad, and the levels of “bad” cholesterol in your blood can be determined with a quick blood test.

To answer the question above, most of the aforementioned Americans with high LDL cholesterol levels in their blood could benefit from some sort of statin therapy. Having said that, it’s important to lean on your family doctor for specific, true to you, medical advice.

How Do They Work?

Now that we know what statins are and who should take them, you might be wondering, how do they work? Statins work by “blocking your body’s production of an enzyme called HMG-CoA reductase,” says Healthline. This is the enzyme that your liver requires to make cholesterol. So, by blocking it your liver will make less cholesterol which in turn reduces your levels.

Further, statins also help your body absorb built-up cholesterol that’s already present in your arteries. It’s important to note, you do need some cholesterol to function, but when your levels get too high that’s when they can wreak havoc on your body.

Common Side Effects

If the previous pages have led you to consider asking your doctor about one of the statins we’ve discussed, temper your expectations. At least until we’ve broken down a few of the most experienced side effects.

Muscle pain is by far the most common side effect, with between 1 and 10 patients reporting muscle-related symptoms. It’s important to note that if you experience muscle pain alongside tiredness, fever, dark urine, or diarrhea, you should reach out to your primary care physician right away!

sore leg muscle

Other Side Effects

Other common side effects include headache, difficulty sleeping, nausea or vomiting, constipation, bloating or gas, rash, flushing of the skin, and more.

When it comes to statins, not all side effects are created equal. There is a rare chance of developing serious side effects, including myositis, elevated levels of CPK, or rhabdomyolysis, all three of which are related to muscle pain and potential long-term muscle damage.

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Risk Factors

While it’s important to be aware of the possible side effects, they won’t happen to everyone. That said, some factors may increase an individual’s risk of developing side effects from statins. This includes taking several medications to lower your cholesterol, or having kidney disease or liver disease.

Mayo Clinic also notes that being female and having a smaller body frame may also increase your risk of developing side effects. Finally, being 80-years old (or older), drinking too much alcohol, or having conditions like hypothyroidism or neuromuscular disorders can also increase your risk.

Statins and Grapefruit

One interesting thing many people might not know is if you take statins, you’ll likely have to avoid grapefruit. This is because the fruit can interact with the drug and cause some side effects to be worse. Healthline notes, “This is especially true with lovastatin and simvastatin.”

With this in mind, if you have to take a statin, make sure you read the warning label. You should also ask your doctor if you’ll need to avoid grapefruit or any other foods or medications while taking statins.

How to Relieve the Side Effects

If you do experience side effects from statins, there may be a few ways you can get some relief. For starters, your doctor may recommend changing your dosage or you may need to take a break from statin therapy.

Further, you may benefit by changing to another statin drug, or you may need to consider a different medication to lower your cholesterol altogether. But whatever method you try, make sure you do so with the guidance and recommendation from your doctor.

Reasons Not to Take Statins

There are a lot of reasons not to take statins, most of which are very personal. You may be turned off by the uncertainty of side effects, you may lack the consistency required to take the medication regularly, or you might just prefer a more natural approach.

If you do decide you don’t want to take statins, be sure to discuss it with your doctor to find out what other options you have.

Natural Alternatives to Lower Cholesterol

There are indeed natural alternatives to lowering your cholesterol levels. Red yeast rice, psyllium, fish oil, or fenugreek supplements have been shown to lower cholesterol, though those supplements may cause side effects too.

There’s also the option to integrate concrete, healthy-living changes into your daily routine. Consuming more sources of HDL cholesterol, exercising 30 to 60-minutes per day, eating more fiber and complex carbohydrates, and reducing the amount of LDL cholesterol that you consume can help too.

A Note on Statins

Statins are an important, life-saving drug that can help lower the risk of heart disease-related illness and death in millions of Americans every single day. There are side effects, and there are more natural changes that you can make to offset those cholesterol levels, but options are always good.

It’s important to note that none of these drugs or health decisions should be made without the professional advice of a licensed practitioner. Health care isn’t one-size-fits-all. It’s a process that relies on tests, medical history, lifestyle choices, and professional acumen to make the smartest choice.

If you suspect that you may need statins, talk to your doctor, and take the required tests to make the best-enlightened decision you can.

Chris Brown

Chris Brown

Chris is a Canadian who loves ice-hockey, espresso, and really long books. He’s an early riser that relies on a combination of meditation, yoga, indoor cycling, and long walks to keep fit. Chris is also a multi-platform content creator with a portfolio that includes terrestrial radio, television, the written word, and YouTube. For more content, check out his podcast, “Black Sheep Radio,” or follow @notTHATcb on Twitter and Instagram