2. The very first PAH case…
The first recorded PAH diagnosis can be traced back to Germany in 1891. Unfortunately at the time the patient succumbed to the disease, which caused the thickening of the pulmonary artery with no trace of heart or lung disease.
3. Primary Pulmonary Hypertension
It wasn’t until 1951 that an America physician by the name of Dr. D.T. Dresdale encountered 3 separate cases of high blood pressure of the main artery of the lungs with no apparent cause, and dubbed the condition Primary Pulmonary Hypertension (or PPH).
4. Diagnosing PAH
Patients affected with PAH often go years without a formal diagnosis. This is often due to their ignoring of milder symptoms that come and go with exercise or other physical excretion.
5. Telltale Symptoms of PAH
This progressive disease begins with mild symptoms—such as shortness of breath, chest pain, and fainting—typically brought on by exercise or strenuous physical activity. That’s why it’s easy to shrug off symptoms in the early stages of the condition.
6. Causes of PAH
Although many factors are thought to contribute to PAH, more than 15-percent of all patients have heritable PAH caused by one of two things:
- Have a family history of PAH
- An autosomal dominant genetic condition caused by mutations in the BMPR2 gene or TGFbeta pathway
- Diet drug use has also been linked to PAH development—i.e., Fen Phen, Pondimin, Redux, and methamphetamines.